Phenylpropanoids and polyketides
Apexbio Technology LLC (E,E)-Bisdemethoxycurcumin 33171-05-0 50mg
(E E)-Bisdemethoxycurcumin (CAS 33171-05-0) is a naturally derived curcuminoid and a structural analog within the demethoxycurcumin class Research demonstrates that this compound modulates multiple inflammatory signaling pathways and alters the expression of various inflammatory mediators It has been shown to induce cell cycle arrest promote apoptosis in cancer cells and inhibit proliferation-related pathways (E E)-Bisdemethoxycurcumin is widely utilized in studies investigating the molecular mechanisms of inflammation tumor cell biology and the pharmacological properties of curcuminoid derivatives
Selleck Chemical LLC Curcumin analog C1
Curcumin analog C1 (Curcumin analog Compound C1) is a potent transcription factor EB (TFEB) activator with promise for the prevention or treatment of Alzheimer s disease
![Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000211898.png-250.jpg)
Medchemexpress LLC (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1S)-1-phenylethyl]prop-2-enamide | 133550-37-5 | MFCD00209855 | 97.0% | 308.33 g/mol | C18H16N2O3 | 1 ML
(+)-Tyrphostin B44 is the (+) enantiomer of Tyrphostin AG-835, a small-molecule inhibitor of the epidermal growth factor receptor (EGFR) used in biochemical and cellular research. It is provided as a concentrated solution in DMSO for in vitro assays and is documented with supporting datasheet, certificate of analysis, and safety data information.
- Provides EGFR inhibitory activity useful for signaling and cancer research.
- Supplied as a 10 mM solution in DMSO for ready-to-use preparations.
- High purity suitable for research applications (≈97%).
- Characterized molecular properties for accurate dosing in assays.
- Documentation available to support safe handling and experimental reproducibility.
TARGETMOL CHEMICALS INC UMBRALISIB R-ENANTIOMER 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202. The IC50 of Umbralisib R-enantiomers against (delta)PI3 kinase is at least 20 times lower than that of the inhibitors against other PI3K isoforms (A (beta) and (gamma)). purity: 95%
Selleck Chemical LLC AMG-458 S2747-5mg
AMG 458 is a potent c-Met inhibitor with Ki of 1 2 nM 350-fold selectivity for c-Met than VEGFR2 in cells
Medchemexpress LLC Tyrphostin 8 | 3785-90-8 | MFCD00020189 | 98.0% | 170.17 g/mol | C10H6N2O | 50 MG
Tyrphostin 8 is a small-molecule research compound that acts as a weak epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor and a more potent inhibitor of the serine/threonine phosphatase calcineurin. Supplied as a solid for laboratory research, it is intended for research use only.
- Small-molecule inhibitor of EGFR and calcineurin (EGFR IC50 560 μM; calcineurin IC50 21 μM).
- High purity: 98.0%.
- Chemical formula C10H6N2O; molecular weight 170.17 g/mol.
- CAS number 3785-90-8.
- Soluble in DMSO at ≥ 100 mg/mL.
- Appearance: light yellow to yellow solid.
- Storage: store at 4°C under nitrogen; in solvent store at -80°C (6 months) or -20°C (1 month).
- For research use only; not for human or clinical applications.
Medchemexpress LLC Entacapone | 130929-57-6 | MFCD00866580 | C14H15N3O5 | 1 ML
Entacapone is a potent, reversible, peripherally acting, and orally active catechol-O-methyltransferase (COMT) inhibitor. It is selective for COMT over other catecholamine metabolizing enzymes. It inhibits COMT from rat brain, erythrocytes, and liver with IC50 values of 10 nM, 20 nM, and 160 nM, respectively. Entacapone can be used for Parkinson's disease research and as an inhibitor of FTO demethylation with an IC50 of 3.5 μM, making it useful for research into metabolic disorders.
- Potent, reversible, peripherally acting, and orally active COMT inhibitor
- Selective for COMT over other catecholamine metabolizing enzymes
- Inhibits COMT from rat brain, erythrocytes, and liver
- Utilized in Parkinson's disease research
- Functions as an inhibitor of FTO demethylation
- Applied in metabolic disorders research
Medchemexpress LLC Ferulic acid 4-O-sulfate | 86321-29-1 | 98.07% | 274.25 | 50 MG
Ferulic acid 4-O-sulfate is a metabolite of Ferulic acid that relaxes arteries and lowers blood pressure in mice. This compound causes significant concentration-dependent relaxations in mouse aorta, femoral and saphenous arteries.
- Relaxes arteries and lowers blood pressure
- Suitable for in vitro and in vivo studies
- Significant concentration-dependent relaxations in mouse arteries
Chem-Impex International, Inc. trans-4-Bromocinnamic acid | MFCD00004394 | 5G
trans-4-Bromocinnamic acid, MFCD00004394, 5G
Medchemexpress LLC 2-Hydroxycinnamic acid | 614-60-8 | HY-W012531 | 99.9% | 164.16 | 25 G
2-Hydroxycinnamic acid is a phenolic acid with antimicrobial and antioxidant properties. It demonstrates antimicrobial activity against *Staphylococcus aureus* without developing resistance, and shows inhibitory effects on HIV/SARS-CoV S pseudovirus infection. Additionally, it exhibits neuroprotective and antitumor activity.
- Possesses antimicrobial and antioxidant properties.
- Exhibits antimicrobial activity against *Staphylococcus aureus*.
- Shows inhibitory effects on HIV/SARS-CoV S pseudovirus infection.
- Has neuroprotective activity.
- Demonstrates antitumor activity.
Medchemexpress LLC 4-(3-Fluorobenzyloxy)benzaldehyde | 66742-57-2 | 99.8% | C14H11FO2 | 100 G
4-(3-Fluorobenzyloxy)benzaldehyde is a chemical compound that serves as a drug intermediate. It is used in the synthesis of various active compounds for research purposes.
- Solid appearance
- Functions as a drug intermediate
- Suitable for the synthesis of active compounds
- For research use only
- Shipped at room temperature in continental US
- Store at 4°C under nitrogen
- When in solvent, store at -80°C for 6 months or -20°C for 1 month under nitrogen
Medchemexpress LLC 3-Methylcinnamic acid | 3029-79-6 | 99.8% | C10H10O2 | 10 G
3-Methylcinnamic acid is a drug intermediate used for the synthesis of various active compounds.
- Used as a drug intermediate
- Suitable for synthesis of various active compounds
- High purity of 99.77%
eMolecules 4'-(4-Fluorobenzyloxy)acetophenone | 72293-96-0 | MFCD00173651 | 25g
Oakwood Chemical | 4'-(4-Fluorobenzyloxy)acetophenone | 25g | 537669236 | 008324 | | 72293-96-0 | MFCD00173651 | 244.265 | C15H13FO2
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Medchemexpress LLC m-Coumaric acid | 588-30-7 | >99.8% | 164.16 | 500 MG
m-Coumaric acid | 588-30-7 | >99.8% | 164.16 | 500 MG
Medchemexpress LLC LASSBio-1135 | 852453-71-5 | 99.1% | 286.33 g·mol^-1 | C18H14N4 | 5 MG
LASSBio-1135 is an orally active TRPV1 antagonist with anti-inflammatory and analgesic activity. It moderately inhibits human PGHS-2 (IC50 = 18.5 μM) and has shown in vivo efficacy by reversing capsaicin-induced thermal hyperalgesia and reducing carrageenan-induced paw edema.
- Orally active TRPV1 antagonist.
- Moderate inhibition of human PGHS-2 (IC50 = 18.5 μM).
- Demonstrated in vivo efficacy in pain and inflammation models.
- High purity suitable for research applications.
- Molecular weight 286.33 g·mol^-1 and formula C18H14N4.
- Available in small research quantities for dosing studies.
- Stable when stored as powder at -20°C for extended periods.